Scientists have discovered nerve cells that directly control insulin production
Co-hosted by IDIBAPS Institute Marc Claret and IRB Barcelona Institute Antonio Zorzano revealed a link between hypothalamic POMC neurons and insulin release from the pancreas and described the molecular mechanisms involved in this association.
Hypothalamus and pancreas
POMC neurons can detect changes in nutrient availability, and the molecular mechanism is still unclear. In order for the level of metabolism to change with energy, the cells adapt to the cell's needs by altering mitochondrial morphology (mitochondrial motility).
To determine whether mitochondrial motility in damaged POMC neurons causes metabolic changes, the researchers removed mouse POMC neuron mitochondrial motor protein Mitofusin1.
At the beginning, the scientists observed changes in the monitoring and adaptation of the glucose levels in the fasted state and after eating. Later, they found that these defects also led to glucose metabolism disorders caused by reduced insulin secretion. "What is surprising is that neurons are not only involved in feeding control (known), but also in the control of the amount of insulin secreted by the pancreatic beta cells," Zorzano explained.
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