China successfully revealed the molecular mechanism of the "lifetime" of viral regulatory proteins
2023-09-26 06:08:59
On December 15th, the research team of Zhou Xi, a researcher at the Wuhan Institute of Virology, Chinese Academy of Sciences, made significant progress in the study of N-terminal rules of virus-regulated hosts. It was first discovered that viruses can regulate the "lifetime" of proteins by inhibiting the N-terminal regulatory pathway and reveal Its molecular mechanism.
The "lifetime" of intracellular proteins varies greatly from synthesis to degradation. In general, proteins responsible for the necessary structure of cells are relatively long-lived, while proteins responsible for signal regulation tend to have shorter lifetimes. Until the 1980s, American scientists discovered that the N-terminal amino acid type of a protein determines its rate of decomposition in cells. This rule applies to all life forms from pronucleus to eukaryote, and is called the "N-terminal rule." ".
However, for viruses that infect various life types, utilize and regulate various biological processes, whether they can regulate the N-terminal regular pathway and thus affect the life of the protein, the industry has always lacked research.
Zhou Xi's research team found that a small RNA-like virus Drosophila C virus can inhibit the apoptotic pathway in the early stages of infection of Drosophila, and further found that early infection of Drosophila C virus can lead to an N-terminally cleaved cell. Abnormal accumulation of apoptosis-inhibiting proteins. More in-depth studies have found that early infection of Drosophila C virus can specifically inhibit the deamidation process in the N-terminal regular pathway, thereby prolonging the lifespan of apoptosis regulation of Drosophila melanogaster exposed to N-terminal unstable amino acids.
This research was published on the 12th in the comprehensive authoritative journal Life Science Online in the field of life sciences. The editorial commentary "opens the door to the N-terminal rule pathway" and provides a deep understanding of various viruses and N. The interaction mechanism of the end rules lays the theoretical foundation.
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