Progress in cell-level drug metabolism research of microfluidic chip
Release date: 2009-01-12
Recently, the research team of microfluidic chip (1807 group) led by researcher Qin Jianhua and researcher led by Lin Bingcheng from the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences has made progress in the research of cell-level drug metabolism based on microfluidic chips.
The study designed a multi-layer integrated microfluidic chip to immobilize liver microsomes on a chip. The drug was metabolized by chip-immobilized liver microsomes and integrated with downstream chip electrophoresis and cell culture units. The chip can simultaneously perform metabolite detection of drugs and cytotoxicity evaluation of metabolites, showing the ability of microfluidic chips to study complex processes such as drug metabolism, for new drug discovery, pharmacology and toxicology studies, and cell-level drugs. Screening provides an important technology platform. The results were published in the latest issue of Lab on Chip and were selected as cover articles.
The microfluidic chip is a hotspot in the development of current micro-full analysis systems, and is the main platform for the implementation of microfluidic technology. Its device features primarily that its effective structure (channels, reaction chambers, and other functional components) that accommodate fluids is on the order of micrometers at least one latitude. Due to the micron-scale structure, the fluid exhibits and produces special properties that differ from the macroscopic scale. This has led to the development of unique analytical performance. ——Shanghai Medical Device Industry Association
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