Cell Magazine: The Chinese Academy of Sciences and NIH collaborate to reveal the key pathways to reverse the aging of human stem cells
Liu Guanghui Laboratory of the Institute of Biophysics, Chinese Academy of Sciences and the National Institutes of Health (NIH) National Cancer Institute Tom Misteli research team, through the screening of genes that reverse the aging potential of human cells, found that the transcription factor NRF2 (NF-E2-related factor 2) The mediated disorder of the cellular antioxidant pathway is the driving force for cell senescence. Further, by screening small molecule compounds having the function of activating the NRF2 pathway, it was found that an NRF2 agonist, Oltipraz, for treating fatty liver can delay the aging process of mesenchymal stem cells and increase their activity in vivo. The research results were published in the June issue of Cell.
Figure: The disorder of the NRF2 antioxidant pathway is the driving force for stem cell senescence in children with premature aging (cited from CELL 2016)
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