Application technology of oral solid preparation medicinal excipients

**Foreword** Pharmaceutical excipients are essential components of drug formulations, playing a critical role in ensuring the efficacy, safety, and stability of medicinal products. A pharmaceutical dosage form refers to the physical state of a drug when it is administered to a patient, such as tablets, capsules, or suspensions. These dosage forms are created by combining the active pharmaceutical ingredient (API) with excipients through specific formulation technologies, resulting in a product that can be directly used for therapeutic purposes. The choice of an appropriate dosage form is crucial because it determines how the drug is absorbed, distributed, metabolized, and excreted in the body. Excipients not only enhance the physical properties of the drug but also ensure its controlled release, bioavailability, and targeted delivery. For example, some excipients help in the dissolution of poorly soluble drugs, while others aid in the formation of stable drug particles or improve the flowability of powders during manufacturing. Excipients also play a vital role in maintaining the integrity of the drug during storage and transport. They prevent degradation, reduce the risk of microbial contamination, and improve the overall appearance and palatability of the final product. The development and application of new excipients have significantly advanced the field of drug delivery, enabling the creation of innovative dosage forms such as sustained-release, controlled-release, and targeted delivery systems. In recent years, the global pharmaceutical industry has witnessed rapid advancements in excipient technology, driven by the need for more effective, safer, and patient-friendly drug products. Countries with well-established pharmaceutical sectors have invested heavily in research and development of novel excipients, leading to the emergence of specialized institutions dedicated to this area. These innovations have not only improved the quality of existing formulations but also paved the way for the development of new therapeutic approaches. In China, the use of pharmaceutical excipients has evolved over time, from traditional materials like starch and honey to modern, high-performance excipients that meet international standards. The introduction of advanced excipients has helped address long-standing challenges in formulation, such as poor tablet hardness, inconsistent disintegration, and limited bioavailability. Moreover, the integration of excipients into film-coating, granulation, and direct compression processes has enhanced the efficiency and consistency of pharmaceutical production. The selection of excipients must be based on a thorough understanding of both the drug’s properties and the intended dosage form. Factors such as solubility, stability, compatibility, and processability all influence the choice of excipients. For instance, in solid dosage forms like tablets and capsules, excipients such as fillers, binders, disintegrants, and lubricants are carefully selected to optimize performance and ensure uniformity. As the pharmaceutical landscape continues to evolve, the role of excipients will become even more significant. With the increasing focus on personalized medicine and advanced drug delivery systems, the demand for high-quality, versatile excipients will only grow. Therefore, ongoing research, innovation, and collaboration between academia, industry, and regulatory bodies are essential to ensure that excipients continue to support the development of safe, effective, and patient-centered therapies.

Pharmaceutical Grade

Shikonin is a kind of organic substance, which is insoluble in water, soluble in ethanol, organic solvent and vegetable oil. It is easy to dissolve in alkali water and precipitate when meeting acid. It can be used in the treatment of acute icteric or non icteric hepatitis, chronic hepatitis and verruca plana. It is also effective for cirrhosis (ascites) and verruca vulgaris. It has anti-cancer, anti-inflammatory, antibacterial and other effects. It is used in the treatment of acute and chronic hepatitis and cirrhosis (ascites). The Department of Dermatology and Hepatology is used for the treatment of verruca plana and psoriasis, local application for the treatment of burns and promoting wound healing. Eye drops are effective in the treatment of herpes simplex keratitis.

Product Name: Shikonin

Other Name : Shikonin Powder

Specification: 10%/30%/ 98%

Appearance: Dark Red Purple Powder

Form: Powder

Storage: Store in cool and dry places, keep away from strong light.

1.Shikonin extract shikonin with the function of anti-tumor effects;

2.Shikonin extract shikonin acts the main role of the cardiovascular system;

3.Shikonin extract shikonin with acne and anti-inflammatory cosmetic effects;

4.Shikonin extract shikonin is mainly used for hepatitis, dermatitis and baby, women vaginitis, cervicitis, and other drugs

5.Shikonin has antimicrobial, anticancer and anti-inflammatory effect.

6.Shikonin is used in treating chronic hepatitis, oxyhepatitis and cirrhosis.

7.Shikonin is used in treating verruca plana and psoriasis.

8.Shikonin is also known to have wound healing, antitumor, and antithrombotic properties.

9.Shikonin works as colorant in cosmetic and food products.

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