Selection points of antibiotic bottle filling machine
2021-08-04 12:23:45
Take the double-head screw type packaging machine as an example, other models can refer to the corresponding changes.
1. Mode and function (1) Double-screw volumetric metering, the whole process of filling (including bottle, bottle, packing and capping) is under the protection of 100-level laminar flow, and no foreign matter is allowed to fall.
(2) The volume and error of the packaging meet the requirements of the Chinese Pharmacopoeia (2000).
(3) The rubber plug can be automatically oriented, dropped and plugged. Adding powder and rubber plugs must be kept under sterile conditions and foreign matter, while maintaining the continuous operation of the dispenser during the addition process.
2, structure and manufacturing 2.1, the overall material and structure (1) all parts directly in contact with the powder are made of high-quality austenitic stainless steel or other materials that do not chemically change with the chemical, do not corrode and do not absorb the drug, external exposed and external The surface is made of stainless steel.
(2) Parts that should be dismantled frequently should be disassembled and assembled conveniently. There is no dead angle and no threaded nano-powder structure, which is convenient for cleaning and suitable for high temperature sterilization.
2.2. Dispensing head, powder storage and powder conveying part (1) The mechanism of dispensing powder must ensure that no metal and other debris are produced.
(2) The powder should not be splashed on the outside of the bottle and should be provided with a collecting structure.
(3) The sub-assembly structure should be simple and detachable and easy to clean. The metering screw should adopt a conical surface that is easy to center and easy to assemble and disassemble. At the same time, there should be no threaded exposed connection.
(4) The sealing head, powder storage and powder feeding passages have good sealing performance to ensure no powder leakage. The powder level control can be achieved by the powder level probe. When the powder level observation window is used, no seams should appear.
(5) It should be equipped with 2~3 kinds of metering screw and lower powder mouth of different specifications to meet the requirements of different materials.
2.3. Rubber plug conveying and pressure plug (1) The contact part of the whole rubber plug is polished to be smooth and polished to ensure that the rubber plug does not generate particles during the operation of the machine.
(2) Electromagnetic oscillating conveying plate or pin-type mechanical conveying plate should operate with low noise. The guiding structure in the conveying plate should ensure the function of eliminating the reverse and overlapping functions, so that the rubber plug enters the track correctly, and the track has no jam. .
(3) The plugging action is in place correctly, the vacuum suction plug is basically not plugged, and the plugging action ensures that the rubber plug is pressed.
2.4, the transport mechanism (1) can ensure that the transport can automatically enter and exit the bottle. The rotating speed of the turntable is stable and basically does not cause bottle down phenomenon. Each bridge should be balanced and properly passed through the bottle.
(2) The mechanism shall be provided with an inverted bottle rejection function, and the conveyor chain shall be provided with an overload protection device such as broken glass.
2.5, other (1) exposed rotating parts should be provided with a relatively sealed protective cover.
(2) Safety device: There must be a mechanical overload protection device.
3, electrical and control 3.1, interlocking and control (1) machine speed can be frequency control, and can display. At the same time, the rubber plug can transmit the oscillation frequency or speed.
(2) When the following conditions occur, it should be automatically stopped and alarmed: a when the metering screw touches the powder port; b when the conveyor chain or the bottle indexing plate is stuck, etc.
(3) Bottles are not packed, and conditions can be set without bottle.
(4) There is no rubber plug storage and the alarm when the powder bucket is short of powder.
(5) PLC control, which can dynamically reflect the main process. It can mainly reflect the number of steps of the metering motor (corresponding to the load relationship), and can automatically count and reflect the shift production.
(6) There should be a man-machine dialogue, which can have the choice of process menu and parameter setting. It can arbitrarily set parameters such as initial frequency, acceleration slope, running frequency, stop deceleration slope and termination frequency, which can reflect faults online. Method of exclusion.
3.2. Loading precision control (1) In addition to adjusting the corresponding metering screw specifications for different loadings and materials, the packing capacity is easy to adjust and has considerable stability, that is, no adjustment is required. It is easy to adjust to the corresponding accuracy requirements for different loads.
(2) When the measurement parameters are set, the control system has automatic deviation correction control to control the parameter change within the set range.
3.3. Connectivity: It can accept and control the shutdown or deceleration commands required for the next process.
3.4. The installation environment requires 100 cleanliness space at the whole machine, that is, the whole process of packing (including bottle, bottle, sub-package, and plug) is under the protection of 100-level laminar flow.
3.5, the main control indicators (1) automatic cover rubber plug success rate ≥ 99%;
(2) When the metering screw touches the powder mouth, it automatically stops and the alarm action completion rate is 100%;
(3) The bottle completion rate is 100%;
(4) When working, the breakage rate of the squeeze bottle is <0.1‰;
(5) Packing speed, in line with production requirements;
(6) Accuracy of sub-package loading, the loading error is in line with the Chinese Pharmacopoeia.
(7) The test for insoluble particles when dispensing powder should comply with the requirements of the insoluble particulate inspection method in the Chinese Pharmacopoeia (Appendix IXC).
1. Mode and function (1) Double-screw volumetric metering, the whole process of filling (including bottle, bottle, packing and capping) is under the protection of 100-level laminar flow, and no foreign matter is allowed to fall.
(2) The volume and error of the packaging meet the requirements of the Chinese Pharmacopoeia (2000).
(3) The rubber plug can be automatically oriented, dropped and plugged. Adding powder and rubber plugs must be kept under sterile conditions and foreign matter, while maintaining the continuous operation of the dispenser during the addition process.
2, structure and manufacturing 2.1, the overall material and structure (1) all parts directly in contact with the powder are made of high-quality austenitic stainless steel or other materials that do not chemically change with the chemical, do not corrode and do not absorb the drug, external exposed and external The surface is made of stainless steel.
(2) Parts that should be dismantled frequently should be disassembled and assembled conveniently. There is no dead angle and no threaded nano-powder structure, which is convenient for cleaning and suitable for high temperature sterilization.
2.2. Dispensing head, powder storage and powder conveying part (1) The mechanism of dispensing powder must ensure that no metal and other debris are produced.
(2) The powder should not be splashed on the outside of the bottle and should be provided with a collecting structure.
(3) The sub-assembly structure should be simple and detachable and easy to clean. The metering screw should adopt a conical surface that is easy to center and easy to assemble and disassemble. At the same time, there should be no threaded exposed connection.
(4) The sealing head, powder storage and powder feeding passages have good sealing performance to ensure no powder leakage. The powder level control can be achieved by the powder level probe. When the powder level observation window is used, no seams should appear.
(5) It should be equipped with 2~3 kinds of metering screw and lower powder mouth of different specifications to meet the requirements of different materials.
2.3. Rubber plug conveying and pressure plug (1) The contact part of the whole rubber plug is polished to be smooth and polished to ensure that the rubber plug does not generate particles during the operation of the machine.
(2) Electromagnetic oscillating conveying plate or pin-type mechanical conveying plate should operate with low noise. The guiding structure in the conveying plate should ensure the function of eliminating the reverse and overlapping functions, so that the rubber plug enters the track correctly, and the track has no jam. .
(3) The plugging action is in place correctly, the vacuum suction plug is basically not plugged, and the plugging action ensures that the rubber plug is pressed.
2.4, the transport mechanism (1) can ensure that the transport can automatically enter and exit the bottle. The rotating speed of the turntable is stable and basically does not cause bottle down phenomenon. Each bridge should be balanced and properly passed through the bottle.
(2) The mechanism shall be provided with an inverted bottle rejection function, and the conveyor chain shall be provided with an overload protection device such as broken glass.
2.5, other (1) exposed rotating parts should be provided with a relatively sealed protective cover.
(2) Safety device: There must be a mechanical overload protection device.
3, electrical and control 3.1, interlocking and control (1) machine speed can be frequency control, and can display. At the same time, the rubber plug can transmit the oscillation frequency or speed.
(2) When the following conditions occur, it should be automatically stopped and alarmed: a when the metering screw touches the powder port; b when the conveyor chain or the bottle indexing plate is stuck, etc.
(3) Bottles are not packed, and conditions can be set without bottle.
(4) There is no rubber plug storage and the alarm when the powder bucket is short of powder.
(5) PLC control, which can dynamically reflect the main process. It can mainly reflect the number of steps of the metering motor (corresponding to the load relationship), and can automatically count and reflect the shift production.
(6) There should be a man-machine dialogue, which can have the choice of process menu and parameter setting. It can arbitrarily set parameters such as initial frequency, acceleration slope, running frequency, stop deceleration slope and termination frequency, which can reflect faults online. Method of exclusion.
3.2. Loading precision control (1) In addition to adjusting the corresponding metering screw specifications for different loadings and materials, the packing capacity is easy to adjust and has considerable stability, that is, no adjustment is required. It is easy to adjust to the corresponding accuracy requirements for different loads.
(2) When the measurement parameters are set, the control system has automatic deviation correction control to control the parameter change within the set range.
3.3. Connectivity: It can accept and control the shutdown or deceleration commands required for the next process.
3.4. The installation environment requires 100 cleanliness space at the whole machine, that is, the whole process of packing (including bottle, bottle, sub-package, and plug) is under the protection of 100-level laminar flow.
3.5, the main control indicators (1) automatic cover rubber plug success rate ≥ 99%;
(2) When the metering screw touches the powder mouth, it automatically stops and the alarm action completion rate is 100%;
(3) The bottle completion rate is 100%;
(4) When working, the breakage rate of the squeeze bottle is <0.1‰;
(5) Packing speed, in line with production requirements;
(6) Accuracy of sub-package loading, the loading error is in line with the Chinese Pharmacopoeia.
(7) The test for insoluble particles when dispensing powder should comply with the requirements of the insoluble particulate inspection method in the Chinese Pharmacopoeia (Appendix IXC).
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Zhoushan City Shuangying Aquatic Products Co., Ltd.  , https://www.shuangying-aquatic.com