American scientists have developed a new type of cardiac tissue engineering scaffold
Release date: 2008-11-07
In a groundbreaking development, American scientists have introduced a novel cardiac tissue engineering scaffold designed to support the growth of living heart cells into functional heart tissue. This accordion-like honeycomb structure has the potential to treat congenital heart defects and aid in the recovery of tissue damaged by heart attacks.
The innovative scaffold was created by Lisa E. Freed and her team at the Massachusetts Institute of Technology. According to the researchers, this biodegradable material is gradually absorbed by the body, leaving behind new, functional tissue. Its mechanical properties closely mimic those of natural heart tissue, becoming stiffer when stretched in the circumferential direction compared to the longitudinal one.
Furthermore, experiments using neonatal rat heart cells on the scaffold demonstrated directional-dependent electrophysiological properties that closely resemble those of natural heart tissue. The scaffold also exhibits an intrinsic ability to guide the orientation of the cultured heart cells, enhancing their structural organization.
The researchers believe that the method used to develop this scaffold could be adapted for use in other types of tissue engineering. However, they acknowledge some limitations, such as the scaffold’s current thinness, which makes it unsuitable for full-thickness myocardial reconstruction. To address this challenge, the team is exploring multi-layered designs to improve its structural capabilities.
This advancement represents a significant step forward in regenerative medicine, offering hope for more effective treatments for heart disease and tissue repair. ——Shanghai Medical Device Industry Association
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