American scientists have developed a new type of cardiac tissue engineering scaffold
Release date: 2008-11-07
In a groundbreaking development, American scientists have introduced a novel cardiac tissue engineering scaffold that mimics the structure of natural heart tissue. This innovative scaffold, designed with an accordion-like honeycomb pattern, allows living heart cells to grow and form functional heart tissue. It holds great promise for treating congenital heart defects and repairing tissue damage caused by heart attacks.
The scaffold was created by Lisa E. Freed and her team at the Massachusetts Institute of Technology. One of its key features is that it is biodegradable, meaning it gradually dissolves in the body while leaving behind new, functional tissue. Its mechanical properties closely resemble those of natural heart tissue, becoming stiffer when stretched in the circumferential direction compared to the longitudinal direction.
Researchers observed that heart cells grown on this scaffold exhibited directional-dependent electrophysiological properties similar to those found in natural tissues. Moreover, the scaffold itself has an intrinsic ability to guide the alignment of the cultivated heart cells, promoting more organized tissue formation.
The production method used to create this scaffold could potentially be adapted for other types of tissue engineering applications. However, the researchers also acknowledged some limitations. For instance, the current design is too thin to support full-thickness myocardial reconstruction. To address this challenge, they are exploring multi-layered structures to enhance the scaffold's functionality.
This advancement marks a significant step forward in the field of regenerative medicine and could pave the way for more effective treatments for heart diseases. ——Shanghai Medical Device Industry Association
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