I lied to your stomach: the new compound makes you feel "full"

2023-01-26 12:06:15
Recently, in a study published in the journal Gut, scientists from the United Kingdom invented a compound that makes people feel fuller. Initial tests showed that the substance was able to eat less and lose weight slowly. When the intestinal tract breaks down the fiber, it produces proprionate, which gives us a feeling of fullness. The compound takes advantage of the power of proprionate.

Release date: 2014-12-12

Recently, in a study published in the journal Gut, scientists from the United Kingdom invented a compound that makes people feel fuller. Initial tests showed that the substance was able to eat less and lose weight slowly. When the intestinal tract breaks down the fiber, it produces proprionate, which gives us a feeling of fullness. The compound takes advantage of the power of proprionate.

Its composition is an unpleasant soluble powder, but these researchers from Imperial College London and Glasgow University are trying to integrate it into bread and fruit smoothies. However, the researchers stressed that the compound must be eaten regularly to be effective.

The trickiest part of the study was to find a way to transport the proprionate into the colon, because the colon is the place to trigger the release of hormones that control appetite. Therefore, the researchers bound proprionate in a natural carbohydrate found in plants, namely inulin. Once bound, proprionate can safely pass through the digestive system before being released from the inulin by the bacteria.

In the initial test, 20 volunteers took inulin or a new ingredient, IPE, and then asked how much they wanted to eat. The results showed that volunteers who took IPE had less than 14% of food.

In the second study, 49 overweight volunteers added 10 grams of IPE or inulin to their daily diet. After 24 weeks, 6 of the 24 volunteers who took the inulin increased more than 3%, and only 1 of the 25 volunteers who took IPE had the same result.

Professor Gary Frost, who led the study, said: "Adults increase their body weight by an average of 0.3-0.8 kg per year. Molecules like propionate can stimulate the release of gut hormones that control appetite, but this requires you to eat a lot of fiber to get the effect. Therefore, we need to find a new way to control the increase in weight."

Professor David Haslam, chairman of the National Obesity Forum in the UK, said: "If this substance does not affect the taste of the food and the health of the intestines, I would be happy to accept it."

Source: Sina Technology

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