Introduction of new methods for laboratory space sterilization to replace formaldehyde

【Abstract】 At present, pharmaceutical companies generally use the method of fumigation to sterilize the clean areas in the production workshop, such as ozone fumigation, formaldehyde fumigation, lactic acid fumigation or chlorine dioxide, etc., and some advanced enterprises have begun to use vaporization. Hydrogen peroxide is VHP . It is well known that although the method of fumigation can solve the problem of temporary sterilization, it is not a perfect sterilization scheme. VHP is much better than fumigation in various aspects but it is hundreds of thousands, which greatly increases the production cost of the enterprise and is expensive. The price of equipment is difficult to meet the production requirements of domestic pharmaceutical companies. So is there a space sterilization solution that combines the bactericidal advantages of VHP with the needs of pharmaceutical companies? The author has been searching for the frontier of science at home and abroad and finally found the Orpheum dry fog space sterilization system abroad.

[Keywords] clean area disinfection, Orpheum, dry fog space sterilization, Orpheum dry fog space sterilization

What is the artifact of the Orpheum dry fog space sterilization system? I think the gods have long been unable to bear the feeling of embarrassment, please allow me to analyze her.

Orpheum dry fog space sterilization system originated in Europe and France, designed for the new version of GMP , dry fog effect leading the world, electrical energy is converted into mechanical energy to produce 5um dry fog particles plus ultra-high initialization speed, dry fog can quickly cover each In a corner of a space, the microbes colliding with the net to capture the air immediately kill, and the 5um gaseous particles can do Brownian motion in the air, and the diffusion is very good. The dry mist system is more perfect with sporicide (the composition is stable hydrogen peroxide + colloidal silver ion). The stability is not only superior to VHP but also meets the cost control target of the enterprise. It is most suitable for domestic pharmaceutical companies.

Orpheum dry fog space sterilization advantages:

1 , the sterilization effect is good, there is a kill rate of 6 logarithmic values for the black

2 , a broad spectrum of bactericidal ability, can kill more than 200 kinds of microorganisms including bacteria, spores, fungi and viruses

3 , 5um dry fog particles, very good diffusion can spread to every corner, do Brownian motion

4, stable, independent of temperature, PH of

5 , colorless, non-toxic, no residue, safe and reliable

6 , the verification information is complete, easy to pass GMP verification

7 , sterilization time is very short, 2-3 hours to complete the entire sterilization process

8 , imported from Europe, designed for disinfection of clean areas, fully in line with GMP requirements

9 , small size, easy to operate, flexible movement to meet different space needs

10 , cost-effective, saving disinfection costs

As the latest dry fog space sterilization solution, Orphem can meet the A/B zone 10-6 power sterilization requirements and meet the C/D zone 10-4 disinfection requirements at low concentrations .

The feasibility of the scheme can be seen from the chart below.

Clean level

product

Sporicide dosage

Sterilization effect

(black)

Meet the size of the space

Residue

Material compatible

A/B area

Orpheum dry fog + sporicide

3mL/ m3

10-6

About 300 cubic meters

Easy to verify

No corrosion

C/D area

1mL/ m3

10-4

About 1000 cubic meters

Easy to verify

No corrosion

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